Interactions of Biological cells with Bioimprinted Patterns

We will use our extensive experience in pattern formation including our unique capability of replicating the detailed topology of biological cells (Bioimprint) and our extensive knowledge in cell culture and functions to develop a model for studying the effects of substrate patterning on cell behaviour and growth.

We will study for the first time how cells interact with their positive and negative replicas of their exact signature. The outcome will have significant implications for the development of artificial tissues in which cells are affected by their neighbours, the use of implants and scaffolds in tissue repair and regeneration, and in the potential to direct cell function in treatments of pathologies such as cancer or in a diverse set of applications utilising stem cells.

This study is also expected to shed light on how the cells interact with surrounding environment and how patterns affect or guide organs in forming their final shape and size. It will help in developing a model for cell / surface interface interactions and to differentiate between the roles of chemical and topographical environments in cell growth.

We are looking for a candidate with micro-nanofabrication / bioengineering interest and hold a PhD degree in relevant subjects to carryout this exciting work. This project will provide a base for the construction of precisely engineered and controlled surfaces with topologies that will induce cells to develop to the cell phenotype with characteristics appropriate to a therapeutic goal.

Skills required:
• Good understanding of biological cells
• Practical experience in micro/nanofabrication
• Experience in Microscopy and imaging

The term of this appointment is for two years commencing May 2012.

This project is in collaborations with Christchurch School of Medicine

Please download position description and contact Associate Professor Maan Alkaisi for more details